![]() ![]() ![]() The objective of this study was to determine the dynamics of chromatin structure and the expression patterns of DNA binding proteins PRM1 and H3.3 in spermatozoa from bulls with varying fertility. However, molecular and cellular underpinnings of their functions in bull spermatozoa and how these two proteins regulate fertility are not known. Recently, H3.3 has been shown to be bound to actively transcribed regions of the paternal genome therefore, its presence becomes important. Both PRM1 and histone3.3 (H3.3 a variant of H3) are known to play important roles during sperm chromatin condensation. Proper packaging of genome is important both for sperm morphology and physiology as well as for fertilization and embryonic development. Genomic DNA of bull spermatozoa is tightly packaged mostly around Protamine 1 (PRM1) and small amounts of histones such as histone3 (H3) in a much smaller volume compared to somatic cells. ![]()
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